Angela Leung DDS PC | Plasma Rich Fibrin in San Francisco

1131 Mission Road,
South San Francisco, CA 94080
    595 Buckingham Way, Ste 432
San Francisco, CA 94132

Dental Implants and Root Canal Specialist

(415) 681-2697

Mon-Fri: 9am-6pm & Sat: By Appointment

Plasma Rich Fibrin


Q: What is Plasma Rich Fibrin?

A: Plasma Rich Fibrin (L-PRF) is a mesh made by spinning down whole blood and harvesting the platelet and leukocyte containing fibrin fraction.  It is a non-thrombinized autologous graft material that releases growth factors over an extended period of time.  Having the platelets within a non-thrombinized fibrin mesh, along with leukocytes, releases PDGF, VEGF, TGFb, and thrombospodin over 7-14 days, precisely when angiogenesis is peaking and bone growth begins.

PRP requires the use of thrombin to help release growth factors from alpha granules within the platelets.   This sudden releases of cytokines is available for approximately 7-14 hours.  After that, the effect of these growth factors dramatically diminishes.

L-PRF  is superior to PRP and PRGF because there is actually an INCREASE in cytokine relase at the most important time during wound healing.

L-PRF is used to fabricate autogous membranes that can be sutured in place and will increase the biotype of tissue. It can also be used to fabricate plugs for extraction sites and in extraction/immediate implant sites to graft the space between implant and facial plate as an alternative to bone grafting.

Pre-Op Presentation:

Patient presented with a nonrestorable tooth #8.

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Pre-Op Preparation of PRF:

Blood is drawn from the patient and spun in the Process PRF centrifuge.


The PRF is then converted to PRF membranes.



SIte Presevation:

The tooth is atraumatically extracted and the site is grafted.


The grafted site is covered with PRF membranes.

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Healing of Site:

After weeks healing period, site is ready to receive a dental implant.



Delivery of Dental Implant to Site:

Implant fixture is delivered to site and covered with another PRF membrane to facilitate and enhance soft tissue closure.


San Francisco Dentist | Plasma Rich Fibrin. Angela Leung is a San Francisco Dentist.